Progressive Dendritic HCN Channelopathy during Epileptogenesis in the Rat Pilocarpine Model of Epilepsy
نویسندگان
چکیده
منابع مشابه
Progressive dendritic HCN channelopathy during epileptogenesis in the rat pilocarpine model of epilepsy.
Ion channelopathy plays an important role in human epilepsy with a genetic cause and has been hypothesized to occur in epilepsy after acquired insults to the CNS as well. Acquired alterations of ion channel function occur after induction of status epilepticus (SE) in animal models of epilepsy, but it is unclear how they correlate with the onset of spontaneous seizures. We examined the propertie...
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Background: Gap junctions (GJs) provide direct intercellular communications that are formed by hexameric protein subunits, called connexin (Cx). The role of Cxs in epileptogenesis has not received sufficient attention. Hippocampus with critical function in epileptogenesis has a wide network of GJs. We examined the protein expression levels of hippocampal Cx36 (the prominent Cx present between G...
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Recent work has suggested a link between h channels and epilepsy. In this issue of Neuron, Shah et al. demonstrate that a robust, postseizure decrease in h channels during a critical phase of epileptogenesis mechanistically underlies dendritic hyperexcitability in entorhinal-hippocampal pyramidal cells.
متن کاملhippocampal expression of connexin36 and connexin43 during epileptogenesis in pilocarpine model of epilepsy
background: gap junctions (gjs) provide direct intercellular communications that are formed by hexameric protein subunits, called connexin (cx). the role of cxs in epileptogenesis has not received sufficient attention. hippocampus with critical function in epileptogenesis has a wide network of gjs. we examined the protein expression levels of hippocampal cx36 (the prominent cx present between g...
متن کاملAlterations of the electroencephalogram sub-bands amplitude during focal seizures in the pilocarpine model of epilepsy
Introduction: Temporal lobe epilepsy (TLE) is the most common and drug resistant epilepsy in adults. Due to behavioral, morphologic and electrographic similarities, pilocarpine model of epilepsy best resembles TLE. This study was aimed at determination of the changes in electroencephalogram (EEG) sub-bands amplitude during focal seizures in the pilocarpine model of epilepsy. Analysis of thes...
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ژورنال
عنوان ژورنال: Journal of Neuroscience
سال: 2007
ISSN: 0270-6474,1529-2401
DOI: 10.1523/jneurosci.3605-07.2007